Research and Grants

Response-Based Imaging Endpoints for Recurrent Glioblastoma Clinical Trials

Principal Investigators: Benjamin M. Ellingson, Ph.D., Patrick Wen, M.D., and Timothy F. Cloughesy, M.D.

Institute: University of California, Los Angeles and Dana-Farber Cancer Institute

Initiative: Clinical Trials Endpoints

Location: Los Angeles, CA and Boston, MA

The Functional Biology of Germline Predisposition to Oligodendroglioma

Principal Investigator: Robert Jenkins, MD, PhD and Daniel Lachance, MD

Institute: Mayo Clinic

Initiative: Oligodendroglioma Research Grant

Location: Rochester, Minnesota

A phase II study of RAD001 (everolimus) for children with chemotherapy hemotherapy-refractory progressive symptomatic low grade gliomas

Principal Investigator: Mark W. Kieran, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Pediatric Low Grade Glioma (LGG) Initiative

Location: Boston, MA

A Piolot Study of the Association of Inflammation-related genes and Glioblastoma

Principal Investigator: Melissa Bondy, PhD

Institute: MD Anderson Cancer Center

Initiative: Epidemiology Research Grant

Location: Houston, TX

A systems approach to develop Pet imaging radiotraceers for IDH1 mutant glioma

Principal Investigator: Ingo Mellinghoff, MD

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Mary Catherine Calisto Systems Biology Initiative

Location: Manhattan, NY

A tumor suppressor mouse model of glioblastoma

Principal Investigator: Luis F. Parada, PhD

Institute: University of Texas Southwestern Medical Center

Initiative: Unrestricted Grant

Location: Dallas, TX

AACR-NBTS Career Development Award for Translational Brain Tumor Research

Principal Investigator: Markus D. Siegelin, MD

Institute: Columbia University Medical Center

Initiative: Unrestricted Grant

Location: Manhattan, NY

AANS 2009 Translational Research Grant: Promoter methylations in GBM a paradigm beyond methylguanine-DNA MGMT

Principal Investigator: Clark Chen, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Unrestricted Grant

Location: Boston, MA

AANS/CNS Translational Award: The colony-forming antibody cell array: A novel screening strategy to further identify cancer stem cells in human malignant gliomas

Principal Investigator: Stephen Skirboll, MD

Institute: Stanford University

Initiative: Unrestricted Grant

Location: Stanford, CA

ACSVL3- A Novel Therapeutic Target in Malignant Glioma

Principal Investigator: Paul Watkins, MD, PhD

Institute: Kennedy Krieger Inst.

Initiative: Standard Research Grant

Location: Baltimore, MD

Active specific immunotherapy of glioma

Principal Investigator: Dorothee Herlyn, DVM

Institute: The Wistar Institute

Initiative: Unrestricted Grant

Location: Philadelphia, PA

Allelic variation in carcinogen metabolism and brain tumor risk

Principal Investigator: Karl Kelsey, MD, MOH

Institute: Harvard University

Initiative: Unrestricted Grant

Location: Boston, MA

Altered peptide epitopes derived from the anti-apoptotic protein ‘survivin’ may stimulate effective anti-glioma immune responses

Principal Investigator: Michael Ciesielski, PhD

Institute: Roswell Park Cancer Institute

Initiative: Glioblastoma Multiforme Grant

Location: Buffalo, NY

An Investigation into the Basic Biology of Meningiomas

Principal Investigator: Michael McDermott, MD

Institute: University of California, San Francisco

Initiative: Meningioma Research Grant

Location: San Francisco, CA

Analysis of acrylonitile and ethylene oxide mutagenesis and neurooncogenesis via mutational spectra and DNA transfections

Principal Investigator: Vernon E. Walker, DVM, PhD

Institute: Lovelace Respiratory Research Institute

Initiative: Unrestricted Grant

Location: Albuquerque, NM

Analysis of the mismatch repair pathway in chemoresistant human glioblastomas

Principal Investigator: David N. Louis, MD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Anti-HGF Monoclonal Antibody Therapy for Malignant Glioma

Principal Investigator: John Laterra, MD, PhD

Institute: Kennedy Krieger Inst.

Initiative: Unrestricted Grant

Location: Baltimore, MD

Antiangiogenetic immunotherapy of malignant brain tumors

Principal Investigator: John H. Sampson, MD, PhD

Institute: Duke University Medical Center

Initiative: Unrestricted Grant

Location: Durham, NC

Antihistamines and Adult Gliomas

Principal Investigator: Michael Scheurer, PhD, MPH

Institute: MD Anderson Cancer Center

Initiative: The Jean Logsdon Epidemiology Grant

Location: Houston, TX

Applications of lipid-coated midrobubble ultrasonic contrast to the therapy of brain tumors

Principal Investigator: Richard Simon, MD

Institute: University of Connecticut

Initiative: Unrestricted Grant

Location: Farmington, CT

Are neural stem cells a source of brain tumors?

Principal Investigator: Arturo Alvarez-Buylla, PhD

Institute: University of California, San Francisco

Initiative: Unrestricted Grant

Location: San Francisco, CA

Ataxia Telangiectasia (ATM) haplotypes and risk of sporadic and radiation associated meningiomas

Principal Investigator: Siegal Sadetzki, MD, MPH

Institute: The Gertner Institute for Epidemiology and Health Policy Research

Initiative: The Brain Tumor Epidemiology Research Grant

Location: Tel Aviv, Israel

Blockade of glioblastoma tumor progression by specific mRNA translation inhibition

Principal Investigator: David Wells, PhD

Institute: Yale University

Initiative: Glioblastoma Multiforme Grant

Location: New Haven, CT

Blocking autophagy and increasing ER stress to improve therapy of GBM

Principal Investigator: Axel H. Schonthal, PhD

Institute: University of California Keck School of Medicine

Initiative: Standard Research Grant

Location: Los Angeles, CA

Cancer Care and Survivorship

Principal Investigator: Susan Chang, MD

Institute: University of California, San Francisco

Initiative: Quality of Life Research Grant

Location: San Francisco, CA

Cell to cell signaling and control growth and differentiation in brain

Principal Investigator: Achim Gossler, PhD

Institute: Institute for Molecular Biology, Medizinische Hochschule Hannover

Initiative: Unrestricted Grant

Location: Hanover, Lower Saxony

Cellular MRI tracking of neural stem cells: Pre-clinical study

Principal Investigator: Karen Aboody, MD

Institute: Beckman Research Institute

Initiative: Glioblastoma Multiforme Brain Tumor Research Grant

Location: Duarte, CA

Characterization of cell adhesion pathways in childhood sPNET

Principal Investigator: Annie Huang, MD, PhD

Institute: Hospital for Sick Children

Initiative: Standard Research Grant

Location: Toronto, ON

Characterization of the antiglioma effect of icovira new oncolytic adenovirus

Principal Investigator: Juan Fueyo, MD

Institute: MD Anderson Cancer Center

Initiative: Glioblastoma Multiforme Grant

Location: Hanover, NH

Chemokine Receptor Regulation of Oligodendroglioma Growth

Principal Investigator: Shenandoah Robinson, MD

Institute: Case Western Reserve University

Initiative: The Oligo Brain Tumor Fund

Location: Cleveland, OH

Chemotherapy with deferred radiotherapy for treatment na_ve anaplastic oligodendroglioma

Principal Investigator: Andrew B. Lassman, MD

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Michael F. Lewandowski Oligodendroglioma Grant

Location: Manhattan, NY

Chromosome 14q Deletions in Oligodendrogliomas

Principal Investigator: Burt Feuerstein, MD, PhD

Institute: University of California, San Francisco

Initiative: The Oligo Brain Tumor Fund

Location: San Francisco, CA

Colony-forming Antibody Cell Array: A Novel Assay to Screen for Cancer Stem Cells in Human Glioblastoma Multiforme

Principal Investigator: Stephen Skirboll, MD

Institute: Stanford University

Initiative: Glioblastoma Multiforme Grant

Location: Stanford, CA

Combination of oncolytic measles virus derivatives and radiation therapy in the treatment of Glioblastoma Multiforme

Principal Investigator: Evanthia Galanis, MD

Institute: Mayo Clinic

Initiative: Glioblastoma Multiforme Grant

Location: Scottsdale, AZ

Controlling pilocytic astrocytoma growth: Effects of location, age, and telomerase

Principal Investigator: Jeffrey Leonard, MD

Institute: Washington University

Initiative: Low-Grade Glioma Initiative

Location: St. Louis, MO

Coping With High Grade Glioma

Principal Investigator: Bart D. Brigidi, PhD

Institute: Duke University Medical Center

Initiative: Caregiver/Quality of Life Brain Tumor Research Grant

Location: Durham, NC

Critical role of NF-xB activation in necrosis formation in human glioblastoma

Principal Investigator: Suyun Huang, MD, PhD

Institute: MD Anderson Cancer Center

Initiative: Unrestricted Grant

Location: Chicago, IL

Critical role of STAT3 in medulloblastoma immune evasion in genetically engineered mice

Principal Investigator: James Waschek, PhD

Institute: University of California, Los Angeles

Initiative: Advanced Research Grant

Location: Los Angeles, CA

DCC tumor suppressor gene-expression and function in gliomas

Principal Investigator: Michael A. Reale, MD, PhD

Institute: Yale School of Medicine

Initiative: Unrestricted Grant

Location: New Haven, CT

Defining key genetic and epigenetic alterations in oligodendroglioma cancer stem cells; Studying the step-wise transformation of neural stem cells into oligodendroglial cancer stem cells

Principal Investigator: Claudia Petritsch, PhD

Institute: University of California, San Francisco

Initiative: Michael F. Lewandowski Oligodendroglioma Grant

Location: San Francisco, CA

Defining microRNA signaling in malignant gliomas

Principal Investigator: Anna Krichevsky, PhD

Institute: Brigham and Women’s Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Defining the basis of enhanced CXCR4 signaling in brain tumors

Principal Investigator: Joshua B Rubin, MD, PhD

Initiative: Unrestricted Grant

Institute: Washington University School of Medicine

Location: St. Louis, MO

Defining the Role of Foxo Transcription Factors and Sirt1 Deacetylase in Suppressing Glioblastomas

Principal Investigator: Anne Brunet, PhD

Institute: Stanford University

Initiative: Unrestricted Grant

Location: Stanford, CA

Defining the role of p53 in the suppression of glioblastoma

Principal Investigator: Gerard Evan, PhD

Institute: University of California, San Francisco

Initiative: Unrestricted Grant

Location: San Francisco, CA

Dendritic cell and dexosome interaction with glioblastoma multiforme

Principal Investigator: Evan M. Hersh, MD

Institute: University of Arizona

Initiative: Unrestricted Grant

Location: Tucson, AZ

Dendritic cells, oncolytic hsv, and brain tumor immunotherapy

Principal Investigator: Samuel D. Rabkin, PhD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Determining the Natural History of Immunological Response in GBM Patients

Principal Investigator: Amy B Heimberger, MD

Institute: MD Anderson Cancer Center

Initiative: Unrestricted Grant

Location: Houston, TX

Developing a recombinant bispecific antibody to target glioblastoma cancer stem cells

Principal Investigator: Albert Wong, MD

Institute: Stanford University

Initiative: Nick Gonzales GBM Research Grant

Location: Stanford, CA

Development of an in silico systems biology approach to personalizing GBM therapy

Principal Investigator: Santosh Kesari, MD, PhD

Institute: University of California, San Diego

Initiative: Mary Catherine Calisto Systems Biology Initiative

Location: La Jolla, CA

Development of clinically relevant orthotopic xenograft mouse models of childhood low grade glioma from primary tumor tissues

Principal Investigator: Xiao-Nan Li, MD, PhD

Institute: Texas Children’s Cancer Center

Initiative: Pediatric Low Grade Glioma (LGG) Initiative

Location: Houston, TX

Development of permanent juvenile pilocytic astrocytoma cell lines for preclinical trials

Principal Investigator: Kwong Kwok Wong, PhD

Institute: MD Anderson Cancer Center

Initiative: Low-Grade Glioma Initiative

Location: Houston, TX

Effect of Provigil (modafinil) on Metastatic BT Patients with Fatigue due to WBRT

Principal Investigator: Nicholas Avgeropoulos, MD

Institute: Florida Hospital Neuro-Oncology Center

Initiative: Quality of Life Research Grant

Location: Orlando, FL

Effects of the suppressive CNS micro-environment on tumor growth in the brain

Principal Investigator: Paul M. Knopf, PhD

Institute: Brown University

Initiative: Unrestricted Grant

Location: Barrington, RI

Enhancement of radiosurgical effects on brain tumors using neural stem cell-based gene expression

Principal Investigator: Ajay Niranjan, MBBS, MS, MCh

Institute: University of Pittsburgh

Initiative: Unrestricted Grant

Location: Pittsburgh, PA

Enhancing radiosensitivity of medulloblastomas with valproic acid: a preclinical study

Principal Investigator: Xiao-Nan Li, MD, PhD

Institute: Texas Children’s Cancer Center

Initiative: The Andrew Christian Bryce Pediatric Grant

Location: Houston, TX

Enhancing survival and function of glioma-specific T-cells in the tumor microenvironment

Principal Investigator: Michael C. Jensen, MD, PhD

Institute: City of Hope National Medical Center

Initiative: Unrestricted Grant

Location: Duarte, CA

Establishment of a consortium-based tissue bank dedicated to Pediatric LGA

Principal Investigator: Charles D. Stiles, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Pediatric Low Grade Glioma (LGG) Initiative

Location: Boston, MA

Evaluating the Use of a Complementary Therapy Educational Intervention to Facilitate MRI Procedures for Pediatric Brain Tumor Patients

Principal Investigator: Wendy Wornham, MD

Institute: Dana-Farber Cancer Institute

Initiative: NBTF Complementary and Alternative Medicine Grant

Location: Boston, MA

Evaluation of non-synonymouse coding single nucleotide polymorphisms (SNPs) in relation to glioblastoma multiforme (GBM)

Principal Investigator: Margaret Wrensch, PhD

Institute: University of California, San Francisco

Initiative: Glioblastoma Multiforme Research Fund

Location: San Francisco, CA

Evolution of a hypomethylator phenotype in glioblastoma

Principal Investigator: Joseph Costello, PhD

Institute: University of California, San Francisco

Initiative: Unrestricted Grant

Location: San Francisco, CA

Expression and function of neurotrophins in medulloblastoma

Principal Investigator: Scott L. Pomeroy, MD, PhD

Institute: Children’s Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Feasibility of T cell immunotherapy for glioblastoma multiforme

Principal Investigator: Lawrence A. Lamb, PhD

Institute: University of Alabama, Birmingham

Initiative: Unrestricted Grant

Location: Birmingham, AL

Functional genomics analysis of primitive neuroectodermal tumors

Principal Investigator: Paul M. Knoepfler, PhD

Institute: University of California, Davis

Initiative: Unrestricted Grant

Location: Davis, CA

Functions of transforming growth factor-and the epidermal growth factor receptor in the development of glioblastomas

Principal Investigator: Emmett V. Schmidt, MD, PhD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Gene therapy & anti-vascular approaches for treating high-grade gliomas

Principal Investigator: Krys Bankiewicz, MD, PhD

Institute: University of California, San Francisco

Initiative: Richard Anthony Hollow, Jr. Memorial Grant for Complementary and Alternative Medicine

Location: San Francisco, CA

Generation and characterization of conditional cancer mouse models for atypical teratoid/rhabdoid tumor and choid plexus carcinoma

Principal Investigator: Tom Curran, PhD, FRS

Institute: Children’s Hospital of Philadelphia

Initiative: Unrestricted Grant

Location: Philadelphia, PA

Genetic Approaches to New Therapeutic Targets in Brain Cancer

Principal Investigator: Gregory Hannon, PhD

Institute: Cold Spring Harbor Laboratory

Initiative: Unrestricted Grant

Location: Cold Spring Harbor, NY

Genetic targeting of cerebellar stem cells to study development and tumorigenesis

Principal Investigator: Robert Wechsler-Reya, PhD

Institute: Sanford-Burnham Medical Research Institute

Initiative: Unrestricted Grant

Location: La Jolla, CA

Genetically engineered anti-angiogenic anti-tumor cytotoxic lymphocytes: A novel immunotherapeutic strategy for malignant glioma

Principal Investigator: Richard C. Mulligan, PhD

Institute: Children’s Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Genetically engineered anti-glioma CTL’s in a murine model of EGFRvIII expressing tumors

Principal Investigator: Bob S. Carter, MD, PhD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Genetically engineered cells designed to deliver drugs by apoptosis

Principal Investigator: James M. Gallo, PhD

Institute: Fox Chase Cancer Center

Initiative: Unrestricted Grant

Location: Philadelphia, PA

Genome-wide profiling of pediatric diffuse intrinsic pontine glioma

Principal Investigator: Cynthia Hawkins, MD, PhD

Institute: Hospital for Sick Children

Initiative: Standard Research Grant

Location: Toronto, ON

Glioblastoma Multiforme: A model for cellular radioresistance

Principal Investigator: Myles Astor, PhD

Institute: New York Medical College

Initiative: Unrestricted Grant

Location: Valhalla, NY

Glioma cancer stem cells in tumor angiogenesis

Principal Investigator: Jeremy Rich, MD

Institute: Cleveland Clinic

Initiative: Unrestricted Grant

Location: Cleveland, OH

Glioma rejection by natural killer cells and IL-10 producing CD4+ T cells

Principal Investigator: Benjamin Matthew Segal, MD

Institute: University of Rochester

Initiative: Unrestricted Grant

Location: Rochester, NY

Glutamate receptor antagonists in malignant gliomas

Principal Investigator: Maiken Nedergaard, MD, PhD

Institute: University of Rochester

Initiative: Unrestricted Grant

Location: Rochester, NY

GM3 as a novel apoptosis inducing agent for human gliomas

Principal Investigator: Peter McL. Black, MD, PhD

Institute: Brigham and Women’s Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Gorlin syndrome gene in medulloblastoma

Principal Investigator: Allen Bale, MD

Institute: Yale University

Initiative: Unrestricted Grant

Location: New Haven, CT

Harnessing Apoptosis for Medulloblastoma Therapy

Principal Investigator: Vidya Gopalakrishnan, PhD

Institute: MD Anderson Cancer Center

Initiative: Unrestricted Grant

Location: Houston, TX

Heat shock protein vaccine development (SPORE Collaborative)

Principal Investigator: Andrew Parsa, MD, PhD

Institute: University of California, San Francisco

Initiative: SPORE Collaborative Grant

Location: San Francisco, CA

Hedgehog pathway in medulloblastoma

Principal Investigator: Allen Bale, MD

Institute: Yale University

Initiative: Unrestricted Grant

Location: New Haven, CT

High Throughput LOH Analysis of Glioma

Principal Investigator: Oliver Bogler, PhD

Institute: Henry Ford Hospital

Initiative: New Approaches to Brain Tumor Therapy Grant

Location: Detroit, MI

Hypoxia and the Death Gene BNIP3 in Oligodendroglioma

Principal Investigator: David D. Eisenstat, MD

Institute: CancerCare Manitoba

Initiative: The Oligo Brain Tumor Fund

Location: Winnipeg, MB

Identification and characterization of novel substrates of neuronal receptor tyrosine kinases

Principal Investigator: David D. Ginty, PhD

Institute: Johns Hopkins Hospital

Initiative: Unrestricted Grant

Location: Baltimore, MD

Identification and cloning of genes correlating with human astrocytic tumor progression using PCR based differential display of mRNA

Principal Investigator: Peter McL. Black, MD, PhD

Institute: Brigham and Women’s Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Identification and immunologic targeting of HCMV antigens expressed in malignant gliomas

Principal Investigator: Duane Mitchell, MD, PhD

Institute: Duke University Department of Surgery

Initiative: Unrestricted Grant

Location: Durham, NC

Identification of a gene on chromosome 22 involved in the genesis of embryonal brain tumors

Principal Investigator: Deborah E. Schofield, MD

Institute: Children’s Hospital

Initiative: Unrestricted Grant

Location: Hollywood, CA

Identification of genes and cell behaviors regulated by Shh/Gli2 signaling in the cell of origin of a major subtype of medulloblastoma using novel genetic tools in mouse

Principal Investigator: Alexandra Joyner, PhD

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Developmental Neurobiology Research Grant

Location: Manhattan, NY

Identification of genes involved in gliomagenesis of INK4a null mice, Role of the PTEN tumor suppressor in the progression of glioma

Principal Investigator: Ming-Jian You, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Unrestricted Grant

Location: Boston, MA

Identification of genes regulating glial cell behavior in the developing visual system of drosophilia

Principal Investigator: Ulrike Gaul, PhD

Institute: Rockefeller University

Initiative: Unrestricted Grant

Location: Manhattan, NY

Identification of Key Genetic and Growth Control Pathway Changes in JPA that Represent Potential Molecular Targets for Therapuetic Intervention

Principal Investigator: Tobey MacDonald, MD

Institute: Children’s National Medical Center

Initiative: Unrestricted Grant

Location: Washington, DC

Identification of key genetic and growth control pathway changes in pediatric fibrillary astrocytomas (PFA) that represent potential molecular targets for therapeutic intervention

Principal Investigator: David H. Gutmann, MD, PhD

Institute: Washington University School of Medicine

Initiative: Low-Grade Glioma Initiative

Location: St. Louis, MO

Identification of molecular and cellular targets of malignant astrocytoma in a mouse model

Principal Investigator: Yuan Zhu, PhD

Institute: University of Michigan Medical School

Initiative: Unrestricted Grant

Location: Ann Arbor, MI

Identification of Molecular Drivers of Brain Tumor Stem Cell Functions Using a Lentiviral RNAi Screen

Principal Investigator: David M. Sabatini, M.D., Ph.D.

Institute: Whitehead Institute

Initiative: Glioblastoma Multiforme Grant

Location: Cambridge, MA

Identification of novel molecules that function in the PTEN/PI 3-kinase regulated signaling pathway in human glioblastoma cells

Principal Investigator: Hong Sun, PhD

Institute: Yale University

Initiative: Unrestricted Grant

Location: New Haven, CT

Identification of S100B-Expressing Population of Cells as the Origin of Oligodendroglioma

Principal Investigator: William A. Weiss, MD, PhD

Institute: University of California, San Francisco

Initiative: Oligodendroglioma Grant (NBTF)

Location: San Francisco, CA

Identification of signals regulating brain tumor stem cell fate

Principal Investigator: Heiko Wurdak, PhD

Institute: AACR National Brain Tumor Foundation Fellowship in Memory of Bonnie Brooks

Location: San Diego, CA

Identification of the chromosome 19q glioma tumor suppressor gene

Principal Investigator: David N. Louis, MD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Identification of the molecular signature of progressive JPA

Principal Investigator: Elizabeth Maher, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Pediatric Low Grade Glioma (LGG) Initiative

Location: Boston, MA

Identification of therapeutic targets in glioblastoma stem cells

Principal Investigator: Cho-Lea Tso, PhD

Institute: University of California, Los Angeles

Initiative: Glioblastoma Multiforme Grant

Location: Los Angeles, CA

Identification & characterization of novel genetic drivers of glioblastoma

Principal Investigator: Milan G. Chheda, MD

Institute: Massachusetts General Hospital

Initiative: AACR National Brain Tumor Foundation Fellowship in Memory of Bonnie Brooks

Location: Boston, MA

Identifying and overcoming resistance in GBM

Principal Investigator: Minesh Mehta, MD

Institute: American College of Radiology, Radiation Therapy Oncology Group

Initiative: Unrestricted Grant

Location: Philadelphia, PA

Identifying the Genetic changes associated with recurrent Anaplastic Astrocytoma

Principal Investigator: Elizabeth Maher, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Conneely-Kosinski Anaplastic Astrocytoma Research Fund

Location: Boston, MA

IDH1R132H-induced transformation of oligodendrocyte progenitor cells into oligodendroglioma

Principal Investigator: Anders Persson, PhD

Institute: University of California, San Francisco

Initiative: Oligodendroglioma Research Grant

Location: San Francisco, CA

IL13R-alpha2 Peptide Vaccine Against Glioma

Principal Investigator: Maciej S. Lesniak, MD

Institute: University of Chicago

Initiative: The Steven J. Bryant Research Grant

Location: Chicago, IL

Immunotherapy of Malignant Gliomas Using Cytokine-Producing delta gamma-1 34.5 HSV

Principal Investigator: Jacqueline N. Parker, PhD

Institute: University of Alabama, Birmingham

Initiative: Unrestricted Grant

Location: Birmingham, AL

Immunotherapy of Pediatric Brain Tumors (Dendritic cell-GBM fusion cell vaccines)

Principal Investigator: Gregory Plautz, MD

Institute: Cleveland Clinic

Initiative: Unrestricted Grant

Location: Cleveland, OH

Importance of ETS gene expression in glioblastomas

Principal Investigator: Stephen Nimer, MD

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Nick Gonzales GBM Research Grant

Location: Manhattan, NY

Individual Response to Low-Dose Radiation

Principal Investigator: Dora Il’yasova, PhD

Institute: Duke University

Initiative: Epidemiology Research Grant

Location: Durham, NC

Inhibition of PI3K and Cdks in glioma

Principal Investigator: William A. Weiss, MD, PhD

Institute: University of California, San Francisco

Initiative: Standard Research Grant

Location: San Francisco, CA

Inhibition of Regulatory T cell Recovery with an IL-2 Receptor Blocking Antibody

Principal Investigator: John H. Sampson, M.D., PhD

Institute: Duke University

Initiative: Unrestricted Grant

Location: Durham, NC

Integrated pharmacogenomic/pharmacokinomic approach to optimize GBM therapy

Principal Investigator: Markus Bredel, MD, PhD

Institute: University of Alabama, Birmingham

Initiative: Mary Catherine Calisto Systems Biology Initiative

Location: Birmingham, AL

Investigating the role of DNA damage response in gliomagenesis and cancer stem cell resistance to irradiation

Principal Investigator: Eric Holland, MD, PhD

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Standard Research Grant

Location: New York, NY

Investigation of Mismatch Repair Pathway Inactivation in Chemoresistant Glioblastomas

Principal Investigator: Dan Cahill, MD, PhD

Institute: Massachusetts General Hospital

Initiative: Glioblastoma Multiforme Grant

Location: Boston, MA

Investigation of the mechanisms underlying chemoresistance of glioblastoma multiforme to platinum treatment

Principal Investigator: Zhimin Lu, MD, PhD

Institute: MD Anderson Cancer Center

Initiative: Unrestricted Grant

Location: Houston, TX

Jun- and MEF2-mediated apoptosis in medulloblastoma

Principal Investigator: John Y.H. Kim, MD, PhD

Institute: Baylor College of Medicine

Initiative: Unrestricted Grant

Location: Houston, TX

KIAA1549:BRAF genetically-engineered mice for pediatric glioma targeted therapeutic drug discovery and evaluation

Principal Investigator: David H. Gutmann, MD, PhD

Institute: Washington University School of Medicine

Initiative: Innovation Research Grant

Location: St. Louis, MO

Kinase inhibitor therapy using a switchable allele of EGFR

Principal Investigator: William A. Weiss, MD, PhD

Institute: University of California, Irvine

Initiative: Unrestricted Grant

Location: Irvine, CA

Lived Experience of Long Term Survivors of Highly Malignant Brain Tumors

Principal Investigator: Mary Lovely, RN, PhD

Institute: University of California, San Francisco

Initiative: Caregiver/Quality of Life Brain Tumor Research Grant

Location: San Francisco, CA

Long-Term Cognitive Outcome in Low Grade Glioma Patients

Principal Investigator: Denise Correa, PhD, ABPP-CN

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Quality of Life Research Grant

Location: Manhattan, NY

Lysosome-directed drug delivery for binary therapy of brain tumors

Principal Investigator: Takeshi Sano, PhD

Institute: Beth Israel Deaconess Medical Center

Initiative: Unrestricted Grant

Location: Boston, MA

Maintaining health-related quality of life of caregivers of glioblastoma patients: a randomized, two-group, controlled trial

Principal Investigator: Martin Klein, PhD

Institute: VU University Medical Center

Initiative: NBTF/TMF Caregiver Research Grant

Location: Amsterdam, Netherlands

Mapping the epigenomic landscape of oligodendroglioma to elucidate tumor growth and chemosensitivity

Principal Investigator: David Louis, MD

Institute: Harvard Medical School

Initiative: Oligodendroglioma Research Grant

Location: Boston, MA

Mechanisms regulating stem cell behavior in glioma

Principal Investigator: Nadia Dahmane, PhD

Institute: The Wistar Institute

Initiative: Standard Research Grant

Location: Philadelphia, PA

Mechanisms related to the bystander cytocidal effect and the role of the bystander effect in the treatment of meningeal neoplasms

Principal Investigator: Frank D. Vrionis, MD, PhD

Institute: New England Medical Center

Initiative: Unrestricted Grant

Location: Boston, MA

Mice, chickens and hedgehogs: A new transgenic system to study medulloblastoma oncogenes

Principal Investigator: Robert Wechsler-Reya, PhD

Institute: Duke University Medical Center

Initiative: Developmental Neurobiology Research Grant

Location: Durham, NC

MicroRNAs in oligodendroglioma

Principal Investigator: Kenneth Aldape, MD

Institute: MD Anderson Cancer Center

Initiative: Oligodendroglioma Brain Tumor Research Grant

Location: Houston, TX

Mitogenic effect of sonic hedgehog in the CNS of transgenic mice

Principal Investigator: David H. Rowitch, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Unrestricted Grant

Location: Boston, MA

Mitotic Olig2+ in glioma formation

Principal Investigator: Qing Richard Lu, PhD

Institute: University of Texas-Southwestern University

Initiative: Unrestricted Grant

Location: Dallas, TX

Modeling progression from low grade astrocytoma to GBM in genetically engineered mice

Principal Investigator: Terry A. Van Dyke, PhD ME

Institute: University of North Carolina at Chapel Hill

Initiative: Unrestricted Grant

Location: Chapel Hill, NC

Modulation of phosphoinositide-3-Oh kinase (P13-K) activation and glioma phenotype by signaling regulatory proteins

Principal Investigator: Donald M. O’Rourke, MD

Institute: University of Pennsylvania

Initiative: Unrestricted Grant

Location: Philadelphia, PA

Molecular analysis of the SynCAM family of tumor suppressors in the brain

Principal Investigator: Thomas Biederer, PhD

Institute: Yale University

Initiative: Unrestricted Grant

Location: New Haven, CT

Molecular genetics of human brain tumors

Principal Investigator: Elizabeth W. Newcomb, PhD

Institute: New York University Medical Center

Initiative: Unrestricted Grant

Location: Manhattan, NY

Molecular markers of prognosis in pediatric astrocytomas

Principal Investigator: Ian Pollack, MD

Institute: University of Pittsburgh

Initiative: Low-Grade Glioma Initiative

Location: Pittsburgh, PA

Molecular mechanisms of Human Glioma Angiogenesis

Principal Investigator: Shi-Yuan Cheng, PhD

Institute: University of Pittsburgh

Initiative: Unrestricted Grant

Location: Pittsburgh, PA

Molecular pathogenesis of diffuse intrinsic pontine gliomas

Principal Investigator: Suzanne Baker, PhD

Institute: St. Jude Children’s Research Hospital

Initiative: Innovation Research Grant

Location: Memphis, TN

Molecular predictors of chemotherapeutic response and survival in oligodendroglial tumors

Principal Investigator: David N. Louis, MD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Molecular profile based development of accurate immunohistochemical marker for human oligodendrogliomas

Principal Investigator: Catherine Nutt, PhD

Institute: Massachusetts General Hospital

Initiative: The Oligo Brain Tumor Fund

Location: Boston, MA

Molecular targeting of GBM with oncolytic polio recombinants

Principal Investigator: Matthias Gromeier, MD

Institute: Duke University

Initiative: Unrestricted Grant

Location: Durham, NC

Molecular Targeting of Survival Signaling Cascades Activated in Glioma

Principal Investigator: Sheri Holmen, PhD

Institute: Nevada Cancer Institute

Initiative: Glioblastoma Multiforme Brain Tumor Research Grant

Location: Bethesda, MD

Molecularly Guided Clinical Trials for Glioma

Principal Investigator: Paul Mischel, MD

Institute: University of California, Los Angeles

Initiative: Unrestricted Grant

Location: Los Angeles, CA

Monoclonal antibodies reactive with the angiostatin receptor to replace angiostatin as an anti-tumor agent

Principal Investigator: Carol J. Wikstrand, PhD

Institute: Duke University Medical Center

Initiative: Unrestricted Grant

Location: Durham, NC

Neural stem cell based cytokine delivery

Principal Investigator: Hideho Okada , MD, PhD

Institute: University of Pittsburgh

Initiative: North American Brain Tumor Consortium Research Grant

Location: Pittsburgh, PA

Neural stem cells as a novel platform for gene therapy against brain tumors

Principal Investigator: Evan Y. Snyder, MD, PhD

Institute: Children’s Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Neuropsychological and Quality of Life late effects Study for the Treatment of Medulloblastoma/PNET

Principal Investigator: Johnathan Finlay, MB, ChB and Stephen Sands, PsyD

Institute: New York University School of Medicine

Initiative: Unrestricted Grant

Location: Manhattan, NY

Nitric oxide and chemotherapy in GBM

Principal Investigator: Chung Hsu, MD, PhD

Institute: Washington University School of Medicine

Initiative: Lowel B. Miller Memorial Research Grant

Location: St. Louis, MO

Nonpathogenic polio recombinants as therapy for brain tumors

Principal Investigator: Eckard Wimmer, PhD

Institute: SUNY Stony Brook

Initiative: Unrestricted Grant

Location: Stony Brook, NY

Novel Approaches to Angiogenesis Inhibition in Experimental Glioma

Principal Investigator: Myrna R. Rosenfeld, MD, PhD

Institute: Memorial Hospital for Cancer and Allied Diseases

Initiative: Unrestricted Grant

Location: Manhattan, NY

Novel Hedgehog Pathway Antagonists as Potential Medulloblastoma Therapeutics

Principal Investigator: James K. Chen, MD

Institute: Stanford University

Initiative: Unrestricted Grant

Location: Stanford, CA

Novel mechanism of glioblastoma tumorgenesis and therapy

Principal Investigator: Samira Guccione

Institute: Stanford University

Initiative: Standard Research Grant

Location: Stanford, CA

Oncolytic adenoviruses against brain tumor stem cells: the role of autophagy

Principal Investigator: Juan Fueyo, MD

Institute: MD Anderson Cancer Center

Initiative: Unrestricted Grant

Location: Houston, TX

Overcoming Immunosuppression with TGFbeta resistant T cells

Principal Investigator: Edward Roy, PhD

Institute: University of Illinois at Urbana-Champaign

Initiative: Pediatric Research Grant

Location: Champaign, IL

PARG regulation of Temozolomide-induced mitotic checkpoint activation

Principal Investigator: Robert W. Sobol, PhD

Institute: University of Pittsburgh

Initiative: Unrestricted Grant

Location: Pittsburgh, PA

Parrafin-based sequencing of the human kinome in pediatric ATRT

Principal Investigator: Mark W. Kieran, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Innovation Research Grant

Location: Boston, MA

Pathology review and molecular characterization of tumors in familial glioma

Principal Investigator: Melissa Bondy, PhD

Institute: MD Anderson Cancer Center

Initiative: Gliogene International Brain Study

Location: Houston, TX

PAX6 Function in Medulloblastoma

Principal Investigator: Yi-Hong Zhou, MD, PhD

Institute: MD Anderson Cancer Center

Initiative: The Andrew Christian Bryce Pediatric Research Grant for Medulloblastoma/PNET

Location: Houston, TX

Peptide vaccine based immunotherapy for pediatric low grade gliomas

Principal Investigator: Ian Pollack, MD

Institute: University of Pittsburgh

Initiative: Pediatric Low Grade Glioma (LGG) Initiative

Location: Pittsburgh, PA

Petrochemical Exposures and Brain Neoplasms

Principal Investigator: David Christiani, MD

Institute: Harvard School of Public Health

Initiative: Unrestricted Grant

Location: Boston, MA

Preliminary proposal for an association study of glioblastomas and DNA repair genes

Principal Investigator: Roberta McKean-Cowdin

Institute: University of Southern California

Initiative: Epidemiology Research Grant

Location: Los Angeles, CA

Prevalence Study

Principal Investigator: Carol Kruchko

Institute: Central Brain Tumor Registry of the United States

Initiative: Unrestricted Grant

Location: Hinsdale, IL

Prevention of Cognitive Impairment Following Radiation Treatment in Patients with Malignant Glioma

Principal Investigator: James Perry, MD

Institute: Sunnybrook and Women’s College Health Sciences Center

Initiative: Quality of Life Research Grant

Location: North York, ON

Promoter methylation in glioblastoma multiforme-a paradigm beyond MethylGuannine-DNA MethylTransferase (MGMT)

Principal Investigator: Clark Chen, MD, PhD

Institute: Dana-Farber and Broad Institute

Initiative: NBTS-AANS Translational Research Grant

Location: Boston, MA

Prophylactic treatment of depression in malignant brain tumor patients

Principal Investigator: Elana Farace, PhD

Institute: University of Virginia

Initiative: Quality of Life Research Grant

Location: Charlottesville, VA

Proteasome inhibitor mediated reversal of Shh driven tumorigenesis

Principal Investigator: Charles Keller, MD

Institute: University of Texas Health Science Center at San Antonio

Initiative: Standard Research Grant

Location: San Antonio, TX

Radiation Therapy Combined with Pirfenidone for Treatment of Gliomas

Principal Investigator: Sunil Krishnan, MD

Institute: Mayo Clinic

Initiative: Radiation Grant

Location: Rochester, MN

Recruitment of stem/progenitor cells to brain tumor vasculature

Principal Investigator: David Scadden, MD

Institute: Harvard Medical School

Initiative: Unrestricted Grant

Location: Boston, MA

Regional expression and functional role of inhibitors of apoptosis in human GBM

Principal Investigator: Abhijit Guha, MD, FRCSC, FACS

Institute: University of Toronto

Initiative: Glioblastoma Multiforme Grant

Location: Toronto, ON

Regulation of brain tumor angiogenesis by g-protein coupled receptors

Principal Investigator: Calvin Kuo, MD, PhD

Institute: Stanford University

Initiative: Unrestricted Grant

Location: Stanford, CA

Regulation of glioblastoma pathogeneisis by EGFRvIII – STAT3 signaling

Principal Investigator: Azad Bonni, MD, PhD

Institute: Harvard Medical School

Initiative: Standard Research Grant

Location: Boston, MA

Regulation of tumor cell invasion and survival by fibulin-3, a matrix protein uniquely expressed in gliomas

Principal Investigator: Bridget McCarthy, PhD

Institute: Ohio State University

Initiative: Standard Research Grant

Location: Columbus, OH

Rheb GTPase as chemotherapeutic target of farnesyl transferase inhibitors in brain cancer

Principal Investigator: Lawrence Quilliam, PhD

Institute: Indiana University School of Medicine

Initiative: Unrestricted Grant

Location: Indianapolis, IN

Role of microRNA-10a and 10b in Gliobastoma Multiforme

Principal Investigator: Arti Gaur, PhD

Institute: Dartmouth Medical School

Initiative: Standard Research Grant

Location: Hanover, NH

Role of a novel member of the ETS transcription factor/ oncogene family, ESE-1, in human brain tumors

Principal Investigator: Towia Libermann, PhD

Institute: Beth Israel Deaconess Medical Center

Initiative: Unrestricted Grant

Location: Boston, MA

Role of thrombospondin-1 methylation in glioblastoma multiforme

Principal Investigator: Jean-Pierre Issa, MD

Institute: Johns Hopkins Hospital

Initiative: Unrestricted Grant

Location: Baltimore, MD

Role of YKL-40-beta-catenin signaling axis in GBM progression and radio-resistance; MicroRNAs in oligodendroglioma

Principal Investigator: Kenneth Aldape, MD

Institute: MD Anderson Cancer Center

Initiative: Standard Research Grant

Location: Houston, TX

Single-cell functional, genomic transcriptonic analysis of glioblastoma

Principal Investigator: Keith L. Ligon, MD, PhD; J. Christopher Love, PhD; and Matthew Meyerson, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: The Bridge Project

Location: Boston, MA

Single cell molecular pathophysiology of medulloblastoma

Principal Investigator: Peter B. Crino, MD, PhD

Institute: University of Pennsylvania

Initiative: Unrestricted Grant

Location: Philadelphia, PA

Somatic Cell Gene Transfer to Model Medulloblastoma in Mice

Principal Investigator: Daniel W. Fults, MD

Institute: University of Utah School of Medicine

Initiative: Unrestricted Grant

Location: Salt Lake City, UT

STAT3 as therapeutic target for glioblastoma

Principal Investigator: Brent Cochran, PhD

Institute: Tufts University School of Medicine

Initiative: Unrestricted Grant

Location: Boston, MA

Stem cell Polycomb repressor targets and Temozolomide Response in Glioblastoma

Principal Investigator: Shichun Zheng, MD

Institute: University of California, San Francisco

Initiative: Nick Gonzales GBM Research Grant

Location: San Francisco, CA

Stems Cells for Glioma Therapy

Principal Investigator: E. Antonio Chiocca, MD, PhD

Institute: Ohio State University

Initiative: Charles B. Wilson Brain Tumor Research Excellence Grant

Location: Columbus, OH

Stress reduction program for patients with malignant brain tumors and their family caregivers

Principal Investigator: Mladen Golubic, MD, PhD

Institute: Cleveland Clinic

Initiative: Quality of Life Research Grant

Location: Cleveland, OH

Structural and biophysical investigation of plexin and the semaphorin system, as receptor-ligand complex implicated in the progression of brain tumors

Principal Investigator: Dimitar Nikolov, PhD

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Unrestricted Grant

Location: Manhattan, NY

Structural mechanisms of receptor signaling in brain tumor angiogenesis

Principal Investigator: Xiaolin He, PhD

Institute: Northwestern University

Initiative: Unrestricted Grant

Location: Evanston, IL

Study of Brain Angiogenesis Inhibitor-1 in Gliomagenesis and Progression

Principal Investigator: Erwin Van Meir, PhD

Institute: Emory University

Initiative: Glioblastoma Multiforme Grant

Location: Atlanta, GA

Studying the step-wise transformation of neural stem cells into oligodendroglial cancer stem cells

Principal Investigator: Claudia Petritsch, PhD

Institute: University of California, San Francisco

Initiative: Oligodendroglioma Grant (NBTF)

Location: San Francisco, CA

Systemic analysis of microRNA signaling pathways and survival of glioblastoma patients

Principal Investigator: Anna M. Krichevsky, PhD

Institute: Brigham and Women’s Hospital

Initiative: Mary Catherine Calisto Systems Biology Initiative

Location: Boston, MA

Systemic antioxidant and oxidant stress levels

Principal Investigator: Lisa Rogers, DO

Institute: Henry Rod Health System

Initiative: Complementary and Alternative Medicine

Location: Detroit, MI

Systems Approach to overcome brain tumor resistance to molecularly anticancer drugs

Principal Investigator: James M. Gallo, PhD

Institute: Mount Sinai School of Medicine

Initiative: Mary Catherine Calisto Systems Biology Initiative

Location: Manhattan, NY

t(11;22) in Recurrent Malignant Glioma Provides a Novel Therapeutic Target

Principal Investigator: Adrienne C. Scheck, PhD

Institute: Barrow Neurological Institute

Initiative: Unrestricted Grant

Location: Scottsdale, AZ

Targeted and Global Methylation Analysis of Epigenetic Events in the Progression of Oligodendrogliomas in Serial Biopsies

Principal Investigator: John A. Maguire, MD

Institute: Vancouver General Hospital

Initiative: Unrestricted Grant

Location: Vancouver, BC

Targeting Brain Tumor Stem Cells via MELK Inhibition

Principal Investigator: Ichiro Nakano, MD, PhD

Institute: Ohio State University

Initiative: NBTS-AANS Translational Research Grant

Location: Columbus, OH

Targeting CD24 in oligodendroglioma tumor progenitor cells

Principal Investigator: Fraser Sim, PhD

Institute: University at Buffalo

Initiative: The Low-Grade Oligodendroglioma Brain Tumor Research Grant

Location: Buffalo, NY

Targeting glioma cancer stem cells using bone marrow derived mesenchymal stem cells

Principal Investigator: Frederick F. Lang, MD

Institute: MD Anderson Cancer Center

Initiative: Nick Gonzales GBM Research Grant

Location: Houston, TX

Targeting gliomas with a novel inhibitor of the JAK2/STAT3 pathway

Principal Investigator: Amy B Heimberger, MD

Institute: MD Anderson Cancer Center

Initiative: Standard Research Grant

Location: Houston, TX

Targeting, imaging and therapy of gliomas via expression of recombinant biotinylated receptors

Principal Investigator: Xandra O. Breakefield, PhD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Targeting of Olig2 in Oligodendrogliomas

Principal Investigator: Santosh Kesari, MD, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Oligodendroglioma Grant (NBTF)

Location: Boston, MA

Targeting radiation resistance in brain tumor stem cells

Principal Investigator: Anita Hjelmeland, PhD

Institute: Cleveland Clinic

Initiative: Standard Research Grant

Location: Cleveland, OH

Targeting Stromal and Tumor Compartments in Glioblastomas

Principal Investigator: Rakesh K. Jain, PhD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Targeting the hedgehog pathway in pediatric low grade glioma

Principal Investigator: Michael K. Cooper, MD

Institute: Vanderbilt University Medical Center

Initiative: Pediatric Low Grade Glioma (LGG) Initiative

Location: Nashville, TN

The biologic and prognostic role of replicative and oncogene induced senescence in pediatric low-grade gliomas

Principal Investigator: Uri Tabori, MD

Institute: Hospital for Sick Children

Initiative: Low-Grade Glioma Initiative

Location: Toronto, ON

The colony-forming antibody cell array: A novel screening strategy to further identify cancer stem cells in human malignant gliomas

Principal Investigator: Stephen Skirboll

Institute: Stanford University

Initiative: NBTS-AANS Translational Research Grant

Location: Stanford, CA

The edge of chaos: Application of complex adaptive system approach to managing tumor populations

Principal Investigator: Brent A. Reynolds, PhD

Institute: University of Florida

Initiative: Mary Catherine Calisto Systems Biology Initiative

Location: Gainesville, FL

The Effect of Music Assisted Relaxation and Guided Imagery on Pre-and Post-Operative Anxiety, Length of Inpatient Stay and Recovery Period for Patients Undergoing Sereotactic Radiosurgery or Elective Craniotomy Procedures for Patients with Brain Tumors

Principal Investigator: Christopher Rumana, MD

Institute: Tallahassee Memorial Healthcare, Inc.

Initiative: Richard Anthony Hollow, Jr. Memorial Grant for Complementary and Alternative Medicine

Location: Tallahassee, FL

The effects of molecularly targeted therapies on the developing neurogenic niches

Principal Investigator: Joseph Scafidi, DO

Institute: Children’s Research Institute

Initiative: Developmental Neurobiology Research Grant

Location: Washington, D.C.

The Neuro-Oncology Genomics Project

Principal Investigator: David Largaespada, PhD

Institute: University of Minnesota

Initiative: Advanced Research Grant

Location: Minneapolis, MN

The regulation of VEGF expression in brain tumors

Principal Investigator: Henry M Furneaux, PhD

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Unrestricted Grant

Location: Manhattan, NY

The role of FAK and Src in Glioma Invasion and Proliferation

Principal Investigator: Qiang Ding, PhD

Institute: University of Alabama, Birmingham

Initiative: North American Brain Tumor Consortium/New Approaches to Brain Tumor Therapy Grant

Location: Birmingham, AL

The Role of HCMV in Glioma Pathogenesis

Principal Investigator: Charles Cobbs

Institute: University of Alabama, Birmingham

Initiative: Charles B. Wilson Brain Tumor Research Excellence Grant

Location: Birmingham, AL

The Role of HDMX in GBM Oncogenesis and Chemoresistance

Principal Investigator: Hai Yan, MD, PhD

Institute: Duke University Medical Center

Initiative: Standard Research Grant

Location: Durham, NC

The role of hypoxia in neural stem cell mirgration to glioma cells

Principal Investigator: Donghong Zhao, PhD

Institute: Beckman Research Institute

Initiative: AACR National Brain Tumor Foundation Fellowship in Memory of Bonnie Brooks

Location: Duarte, CA

The role of met tyrosine kinase in the regulation of apoptosis in malignant gliomas

Principal Investigator: Hui-Kuo G. Shu, MD, PhD

Institute: University of Pennsylvania

Initiative: Unrestricted Grant

Location: Philadelphia, PA

The Role of NOTCH Cell Signaling and INK4A/ARF Deletion in the Transformation of Radial Glia to Ependymoma Cancer Stem Cells

Principal Investigator: Richard Gilbertson, MD, PhD

Institute: St. Jude Children’s Research Hospital

Initiative: Unrestricted Grant

Location: Memphis, TN

The role of protein kinase C in astrocytomas

Principal Investigator: I. Bernard Weinstein, MD

Institute: Columbia-Presbyterian Cancer Center

Initiative: Unrestricted Grant

Location: Manhattan, NY

The role of PTEN tumor suppressor in regulating neural stem cells and tumorigenesis

Principal Investigator: Xin Liu, MD, PhD

Institute: University of California, Los Angeles

Initiative: Unrestricted Grant

Location: Los Angeles, CA

The role of the fibrinolytic system in development of metastasis to the brain

Principal Investigator: George Perides, PhD

Institute: Beth Israel Deaconess Medical Center

Initiative: Unrestricted Grant

Location: Boston, MA

The Role of Tumor Antigens in the Immunologic Rejection of Brain Tumors (BTEC Pilot Study)

Principal Investigator: Joseph L. Wiemels, PhD

Institute: University of California, San Francisco

Initiative: Epidemiology Research Grant

Location: San Francisco, CA

Towards personalized medicine in neurooncology: multigene predictor of response in glioblastoma

Principal Investigator: Kenneth Aldape, MD

Institute: MD Anderson Cancer Center

Initiative: Glioblastoma Multiforme Grant

Location: Houston, TX

Treatment of Malignant Brain Tumors Via Controlled, Localized Gene Silencing

Principal Investigator: Eben Alsberg, PhD

Institute: Case Western Reserve University

Initiative: The Steven J. Bryant Research Grant

Location: Cleveland, OH

Tumor antigens recognized by T cells in malignant glioma

Principal Investigator: Chris D. Platsoucas, PhD

Institute: Temple University School of Medicine

Initiative: Unrestricted Grant

Location: Philadelphia, PA

Tumorigenic potential of progenitor cells in low-grade oligodendrogliomas.

Principal Investigator: Marcela Assanah, PhD

Institute: Columbia University

Initiative: The Low-Grade Oligodendroglioma Brain Tumor Research Grant

Location: Manhattan, NY

Updating Prevalence and Conditional Survival Estimates for All Primary (Malignant and Non-Malignant) Brain Tumors in the United States

Principal Investigator: Bridget McCarthy, PhD

Institute: University of Illinois at Chicago

Initiative: Unrestricted Grant

Location: Chicago, IL

Use of Phosphoinositide Analogues to Enhance Chemosensitivity: A Novel Adjuvant Chemotherapeutic for Medulloblastoma

Principal Investigator: William C. Broaddus, MD, PhD

Institute: Virginia Commonwealth University

Initiative: The Andrew Christian Bryce Pediatric Grant for PNET Research

Location: Richmond, VA

Validation of GSK-3 as an Anti-Invasive Target in Glioma

Principal Investigator: E. Antonio Chiocca, MD, PhD

Institute: Ohio State University

Initiative: Glioblastoma Multiforme Grant

Location: Columbus, OH

Vascular delivery of an amplifying vector for brain tumor therapy; Targeting, Imaging and Therapy of Gliomas Via Expression of Recombinant Biotinylated Receptors

Principal Investigator: Xandra Breakefield, PhD

Institute: Massachusetts General Hospital

Initiative: Unrestricted Grant

Location: Boston, MA

Wingless Signaling in Medulloblastomas: A Murine Tumor Model

Principal Investigator: Charles Eberhart, MD, PhD

Institute: Johns Hopkins Hospital

Initiative: Unrestricted Grant

Location:Baltimore, MD

YAP1 as an effector of Sonic hedgehog mitogenic signaling in cerebellar development

Principal Investigator: Anna M. Kenney

Institute: Memorial Sloan-Kettering Cancer Center

Initiative: Standard Research Grant

Location: Manhattan, NY

Anti-angiogenic gene therapy for brain tumors

Principal Investigator: Lynn Hlatky, PhD

Institute: Dana-Farber Cancer Institute

Initiative: Unrestricted Grant

Location: Boston, MA

Anti-angiogenic treatment for enhancement of anti-tumor effects of oncolytic viruses

Principal Investigator: Balveen Kaur, PhD

Institute: Ohio State University

Initiative: Glioblastoma Multiforme Grant

Location: Columbus, OH

Characterization and ablation of tumor stem cells in Oligodendroglioma

Principal Investigator: Kyuson Yun, PhD

Institute: Dartmouth Medical School

Initiative: Oligodendroglioma Grant (NBTF)

Location: Hanover, NH

Molecular mechanisms of cytoxicity following drug-induced DNA damage in glioma cell lines

Principal Investigator: Howard Fine, MD

Institute: National Cancer Institute

Initiative: Unrestricted Grant

Location: Bethesda, MD

A Collaborative study of descriptive epidemiology, etiologic risk factors and classifications of oligodendrogliomas: a pilot study

Principal Investigator: Bridget McCarthy, PhD

Institute: University of Chicago

Initiative: Epidemiology Research Grant

Location: Chicago, IL

A cross sectional study of health related quality of life in children

Principal Investigator: Paul Graham Fisher, MD

Institute: Stanford University

Initiative: Pediatric Research Grant

Location: Stanford, CA

A New Target For Immunotherapy of Glioma

Principal Investigator: Boris Minev

Institute: University of California, San Diego

Initiative: Unrestricted Grant

Location: La Jolla, CA

A novel approach to control brain tumor invasion

Principal Investigator: Yi Rao, PhD

Institute: Washington University School of Medicine

Initiative: Charles B. Wilson Brain Tumor Research Excellence Grant

Location: St. Louis, MO

A novel biomarker for glioma stem cells and GBM

Principal Investigator: Kyuson Yun, PhD

Institute: The Jackson Laboratory

Initiative: Unrestricted Grant

Location: Bar Harbor, ME

A Novel Preclinical Mouse Model of Medulloblastoma

Principal Investigator: Michael Taylor, MD, PhD

Institute: Hospital for Sick Children

Initiative: The Andrew Christian Bryce Pediatric Grant

Location: Toronto, ON

Principal Investigator: Michael Taylor, MD, PhD

Institute: Hospital for Sick Children

Initiative: The Andrew Christian Bryce Pediatric Grant

Location: Toronto, ON

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