Brain Tumor Research

Research Progress

What’s New in Brain Tumor Progress

Progress in 2018

The Risk of Alternative Cancer Treatments

October 1, 2018
New York Times

One web-based group, Integrative Cancer Answers, states that as many as 83 percent of cancer patients choose to use one or more forms of alternative medicine, ranging from acupuncture and herbs to vitamins and yoga, most often in conjunction with therapies clinically proven to be effective.

Association of MGMT Promoter Methylation Status With Survival Outcomes in Patients With High-Risk Glioma Treated With Radiotherapy and Temozolomide

June 28, 2018
JAMA Oncology

In this correlative analysis of the NRG Oncology/RTOG 0424 trial, the proportion of patients with MGMT promoter methylation was 57 of 75 (76%) vs 18 of 75 (24%) unmethylated. MGMT promoter methylation was significantly correlated with progression-free and overall survival on univariate and multivariate analyses with and without adjusting for IDH1/2 status (wild type vs mutant).

Modified polio vaccine helps fight deadly brain tumors

June 26, 2018
NBC News

A modified version of the polio vaccine, infused straight into aggressive brain tumors, helped some patients live for years longer than they normally would have, doctors reported Tuesday.

Potential Brain Tumor Treatments Entering the Pivotal Phase of Evaluation – June 2018

June 14, 2018
NBTS Blog

A large, randomized, controlled Phase III clinical trial is traditionally the last, pivotal step in the evaluation of a potential new medicine before it is approved for use by all patients with the indicated disease.

NBTS Brain Tumor Clinical Trials Report: Q2 2018

June 13, 2018
NBTS Blog

New brain tumor clinical trials open around the country all the time, and it can be hard for patients and care-partners to keep track of new opportunities to potentially participate in leading-edge clinical research. This report, generated by the National Brain Tumor Society, provides you with a summary of clinical trials that have started or begun recruitment since our last quarterly report

Immunotherapy of Primary Brain Tumors: Facts and Hopes

June 5, 2018
Clinical Cancer Research

The field of cancer immunotherapy has made exciting progress for some cancer types in recent years. However, recent failures of late phase clinical trials evaluating checkpoint blockade in glioblastoma (GBM) patients represent continued challenges for brain cancer immunotherapy.

Researchers find leukemia and lymphoma drug may benefit glioblastoma patients

May 30, 2018
MedicalXpress

New Cleveland Clinic research shows for the first time that ibrutinib, an FDA-approved drug for lymphoma and leukemia, may also help treat the most common—and deadliest—type of brain tumor. The findings, published in Science Translational Medicine, offer hope that the drug may one day be used in patients with glioblastoma and improve poor survival rates.

Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance

May 30, 2018
Science Translational Medicine

Glioblastoma is a lethal and difficult to treat primary brain tumor. Similar to many cancers, glioblastoma contains a population of stem cells, which are particularly treatment-resistant and promote tumor growth. A protein called bone marrow and X-linked (BMX) nonreceptor tyrosine kinase is active in these cells and can be targeted with ibrutinib, an approved drug used in other cancers.

MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells

May 29, 2018
PNAS

Gliomas exhibit high proportions of glioma stem cells (GSCs), anoikis resistance, increased brain parenchyma invasion, and resistance to therapy with high recurrence. GSCs display protective autophagy, a self-mediated lysosomal degradation process that balances sources of energy at critical times of stress.

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

April 23, 2018
Nature

To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft models derived from them.

Reconstructing the molecular life history of gliomas

April 3, 2018
SpringerLink

At the time of their clinical manifestation, the heterogeneous group of adult and pediatric gliomas carries a wide range of diverse somatic genomic alterations, ranging from somatic single-nucleotide variants to structural chromosomal rearrangements.

Minimally Invasive Resection of Deep-seated High-grade Gliomas Using Tubular Retractors and Exoscopic Visualization.

2018
PubMed

Deep-seated high-grade gliomas (HGGs) represent a unique surgical challenge because they reside deep to critical cortical and subcortical structures and infiltrate functional areas of the brain. Therefore, accessing and resecting these tumors can often be challenging and associated with significant morbidity. We describe the use of minimally invasive approaches to access deep-seated HGGs to achieve extensive resections while minimizing surgical morbidity.

Report: 2018 Defeat GBM Retreat – Priorities for the Future

April 26, 2018
NBTS Blog

Launched in 2013, Defeat GBM is now in its fourth year of funding toward a five-year, $10 million commitment. The disease trajectory goal of Defeat GBM is to conduct “team science” that ultimately leads to doubling the percentage of glioblastoma patients living five years or longer.

Predicting cancer outcomes from histology and genomics using convolutional networks

March 12, 2018
PNAS

Predicting the expected outcome of patients diagnosed with cancer is a critical step in treatment. Advances in genomic and imaging technologies provide physicians with vast amounts of data, yet prognostication remains largely subjective, leading to suboptimal clinical management.

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma

2018
Journal of Clinical Oncology

DNX-2401 (Delta-24-RGD; tasadenoturev) is a tumor-selective, replication-competent oncolytic adenovirus. Preclinical studies demonstrated antiglioma efficacy, but the effects and mechanisms of action have not been evaluated in patients.

NBTS Brain Tumor Clinical Trials Report: January/February 2018

February 15, 2018
NBTS Blog

New brain tumor clinical trials open around the world all the time, and it can be hard for patients and care-partners to keep track of new opportunities to potentially participate in leading-edge clinical research.

2018 Crystal Ball: Predictions & Hopes for Advances in Brain Tumor Research and Treatments in the New Year

January 18, 2018
NBTS Blog

Last year, progress continued to build in the fight against brain tumors. Two products were given FDA approval for use in the treatment of brain tumors, the first such approvals since the Optune device was approved for use in newly diagnosed glioblastoma patients in 2015.

Progress in 2017

Age-Dependent Cellular and Behavioral Deficits Induced by Molecularly Targeted Drugs Are Reversible

March 20, 2017
American Association of Cancer Research

Targeted therapeutics elicit age-dependent long-term consequences on the developing brain that can be ameliorated with environmental enrichment

Machine Learning Classifies Cancer

March 14, 2017
Nature

Machine-based-learning approaches are being developed to aid the diagnosis of clinical samples, and in a paper in Nature, Capper et al.1 report such a method for classifying brain tumours on the basis of molecular patterns.