Under the current system, Dr. Wrensch expanded, “someone with a grade III glioma, for example, may not have been treated as aggressively as someone with a grade IV. But now, if you determine that it’s a TERT-mutated-only tumor, there is more confidence that it will behave more like a grade IV tumor and could be treated more aggressively. A grade III tumor that only has an IDH mutation might be treated les aggressively. Glioma treatments can be very toxic, so it’s important to know how aggressive treatment needs to be.”
Leaders from both study groups were careful to say that their results could benefit from more data and study, especially in terms of the association between genetic make-up and potential survival rates. However, these studies are likely to significantly add to the information and considerations that the World Health Organization is currently reviewing as its looks to issue a revised classification for brain tumors later this year.